I'm with Turtle... Adirondacks are my favorite canoe waters, and there are plenty of loops and in/out trips... Low's can be 3 days or 2 weeks.  Lila, with it's long carry in, can be people free after Labor Day, and there are plenty of side excursions to keep you occupied.  The St Regis Canoe Wilderness is also a favorite... plenty of loop trips there.  The North Forest Canoe Trail is another in/out if you don't want to shuttle, but pretty.