Troy - What are you hoping to accomplish? You mention a timeframe and that you're interested in fishing but are you willing to add carries? If so, how long a carry are you willing to take on? Are you OK with an "in & out" type trip; i.e. beginning and ending at the same location that's not a loop? For that amount of time you could consider traveling the historic route that goes from Old Forge up to Saranac Lake and then return to Old Forge; or some variation of that idea. Years ago some friends of mine did a trip similar to this where they began at Raquette Lake, went up to Saranac and then returned to Raquette. They truly enjoyed themselves but I don't know if this works for you.
Also, in regard to fishing, how important is that to you on this trip? Some folks would travel what would amount to a traditional 3 - 4 day trip but stay in one location to fish for a couple of days before moving on. Would that be something you're interested in?
I think the more you can pin down what it is you want to do and then share that with this forum, the more help you'll receive. Just my thoughts.
That's all for now. Take care and until next time....be well.
snapper